CYC1兔多克隆抗体

一抗 2470
品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210116S CYC1兔多克隆抗体 50ul 1200

Applications

Tested Applications:
IHC, WB,ELISA

Cited Applications:
IHC, WB
Species Specificity:
human, mouse

Cited Species:
human, monkey, mouse, pig

Positive WB detected in:
human brain tissue

Positive IHC detected in:
human liver cancer tissue, human breast cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Recommended dilution:
WB : 1:500-1:2000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cytochrome c-1

Calculated molecular weight:
35 kDa

Observed molecular weight:
35 kDa

Gene symbol
CYC1

Synonyms
Complex III subunit 4, Complex III subunit IV, CYC1, cytochrome c 1, UQCR4

Background

CYC1, also named as Cytochrome c-1, belongs to the cytochrome c family. Cytochrome c1 is one respiratory subunit of the 11 subunits of the cytochrome bc1 complex of the mitochondrial electron-transfer chain. It mediates the transfer of an electron from Rieske iron-sulfur protein to cytochrome c(PMID:3036122 ). CYC1 mediates apoptosis. In this pathway, a variety of apoptotic stimuli cause CYC1 release from mitochondria, which in turn induces a series of biochemical reactions that result incaspase activation and subsequent cell death.(PMID:15189137) While CYC1 release and DNA fragmentation are unaffected by the noncleavablep75 mutant, mitochondrial morphology of dying cells is maintained, and loss of plasma membrane integrity is delayed(PMID:15186778). The protein migrated as a 35 kd band in SDS page.

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