杭州浩克生物
CD45兔单克隆抗体
518Applications Product Information Immunogen Information Background FC, IHC, IP, WB,ELISA human colon tissue, mouse lung tissue, huma...
查看全文Caspase 8兔多克隆抗体
| 品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
|---|---|---|---|---|---|
| KAOKEBIO | HK210070L | Caspase 8兔多克隆抗体 | 200ul | 支 | 2800 |
Applications
Tested Applications:
IF, IHC, IP, WB, ELISA
Cited Applications:
ELISA, IF, IHC, IP, RIP, WB
Species Specificity:
human, mouse
Cited Species:
chicken, human, mouse, rabbit, rat
Positive WB detected in:
Staurosporine treated Jurkat cells, RAW264.7, HeLa cells, Raji cells, Jurkat cells, UV treated Hela, Sp2/0 cells
Positive IP detected in:
HeLa cells, Jurkat cells
Positive IHC detected in:
human lymphoma tissue, human colon tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in:
HepG2 cells
Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100
Product Information
Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Immunogen Information
Full name:
caspase 8, apoptosis-related cysteine peptidase
Calculated molecular weight:
538 aa, 62 kDa
Observed molecular weight:
53-57 kDa, 32-45 kDa
Gene symbol
CASP8
Synonyms
Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase 8/p43/p18, caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MCH5
Background
CASP8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. CASP8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816 ). It may control diabetic embryopathy-associated apoptosis via regulation of the Bid-stimulated mitochondrion/caspase-9 pathway (PMID:19194987). CASP8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. This antibody can recognize the pro- and cleaved-caspase 8.
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