CD23兔单克隆抗体
171Tested Applications: IF, IHC, WB,ELISA Species Specificity: human, mouse Positive WB detected in: Raji...
查看全文品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
---|---|---|---|---|---|
KAOKEBIO | HK210068L | Caspase 6兔多克隆抗体 | 200ul | 支 | 2800 |
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Caspase-6 belongs to caspase family of cysteinyl-aspartate specific proteases.Precursor of CASP6 produces two subunits, large (18kDa) and small (16kDa) that dimerize. It cleaves poly(ADP-ribose) polymerase, as well as lamins and is involved in the activation cascade of caspases responsible for apoptosis execution. Researches showed that CASP6 could be an early instigator of neuronal dysfunction and regulates B cell activation and differentiation into plasma cells by modifying cell cycle entry. IRAK3 is an important target for CASP6. It can reveal five bands of 28, 32, 36, 49, and 64 kDa in human neurons and fetal brain in western blot, the 32 and 28 kDa bands represent procaspase-6 and pro-arm caspase-6. Procaspase-6 is more abundant than pro-arm caspase-6 in adult tissue, whereas pro-arm caspase-6 is more abundant than pro-caspase-6 in fetal brain and cultured neurons. The higher molecular mass bands at 49 and 64 kDa likely represent dimers of p28 and p32.(PMID:10438520). In rat testis, it can be detected two bands of 34 kDa and 12 kDa or 14 kDa(PMID:12538628).
Tested Applications: IF, IHC, WB,ELISA Species Specificity: human, mouse Positive WB detected in: Raji...
查看全文Tested Applications: IF, IHC, WB, ELISA Cited Applications: IF, IHC, WB Species Specificity: Human C...
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