BCL2L1兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210039L BCL2L1兔多克隆抗体 200ul 2800

Applications

Tested Applications:
FC, IF, IHC, IP, WB,ELISA

Cited Applications:
CoIP, IHC, WB

Species Specificity:
human, mouse

Cited Species:
human, mouse, rat

Positive WB detected in:
NIH/3T3 cells, RAW 264.7 cells

Positive IP detected in:
NIH/3T3 cells

Positive IHC detected in:
human testis tissue, human lung cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
HepG2 cells

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-like 1

Calculated molecular weight:
26 kDa

Observed molecular weight:
30 kDa


Gene symbol
BCL2L1

Synonyms
Apoptosis regulator Bcl X, BCL2L1, Bcl-xL

Background

BCL2L1 is a member of the BCL-2 protein family. BCL2L1 is expressed as three isoforms, Bcl-X(L),Bcl-X(s) and Bcl-X(beta), and is located at the outer mitochondrial membrane. The Bcl-XL isoform is a 233 amino acid protein, acting as an apoptotic inhibitor. Bcl-XL can forms heterodimers with BAX, BAK or BCL2, and the heterodimerization with BAX does not seem to be required for anti-apoptotic activity. The Bcl-XS isoform is a shorter variant that is 178 amino acids in length and lacks a 63 amino acid region (amino acids 126-188), acting as an apoptotic activator. This antibody can recognize Bcl-XL, Bcl-XS and Bcl-X(Beta).

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