BDNF兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210043S BDNF兔多克隆抗体 50ul 1200

Applications

Tested Applications:
IF, IHC, WB,ELISA

Cited Applications:
IF, IHC, WB
Species Specificity:
Human, mouse, rat

Cited Species:
human, mouse, rat

Positive WB detected in:
C6 cells, SH-SY5Y cells, PC-12 cells

Positive IHC detected in:
human gliomas tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
PC-12 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:200-1:800
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
brain-derived neurotrophic factor

Calculated molecular weight:
247 aa, 28 kDa

Observed molecular weight:
28-30 kDa

Gene symbol
BDNF

Synonyms
Abrineurin, BDNF

Background

BDNF is a member of the family of neurotrophic factors. It was first explored and purified from pig brain in 1982, and other members of the neurotrophin family were successively discovered. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of BDNF is reduced in both Alzheimer's and Huntington disease patients. It participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. It also plays a role in the regulation of stress response and in the biology of mood disorders. The BDNF gene is rather complex in its structure and it can express five different mRNA isoforms by alternative splicing, producing 28-37 kDa proteins.

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