BAP-1 Recombinant Rabbit Monoclonal Antibody Product Datasheet Catalog# HKZ150278 Clone# BP6255 Predicted Molecular Wt: 80kDa Purity: ProA affinity purified IgG Species Cross-reactivity: Human Form: Liquid Applications: IHC-P Swissprot ID: Q92560 Background: BAP-1 (BRCA-1 Associated Protein-1) is an 80 kDa protein known to function as a deubiquitinase (DUB); removing ubiquitin modifiers, which alter the function of other proteins via targeted degradation, subcellular localization, or activity. By removing ubiquitin, BAP-1 helps regulate the function of target proteins involved in diverse cellular processes. BAP-1 was expressed in most normal cells, but deletion of expression has been found in mesothelioma. Germline mutations in the BAP-1 gene have been associated with BAP-1 tumor predisposition syndrome, a condition linked to early onset and/or increased risk of multiple types of cancers including uveal melanoma, malignant mesothelioma, cutaneous melanoma, and renal cell carcinoma. Subcellular location: Nucleus Recommended Method: Heat induced epitope retrieval with Tris-EDTA buffer (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes. Immunogen: Synthetic peptide. This information is proprietary to Biolynx. Storage Buffer: PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. Storage Conditions: -25°C to -18°C Shipment Instructions: Shipped on blue ice. Upon delivery store at -25°C to -18 °C. Avoid freeze / thaw cycles. Recommended Dilution: IHC-P: 1:100-1:200 Background References: 1. Citterio E. Front Genet. 2015; 6:282. 2. Murali R, Wiesner T, Scolyer RA. Pathology. 2013 Feb; 45(2):116-26. Immunohistochemistry (Formalin/PFA-fixed paraffin- embedded sections) analysis of human mesothelioma labelling BAP-1 with BP6255.
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