ERp19兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK210138M ERp19兔多克隆抗体 100ul 1960

Applications

Tested Applications:
IHC, WB,ELISA
Species Specificity:
human, mouse, rat

Positive WB detected in:
human brain tissue, human heart tissue, mouse kidney tissue, mouse lung tissue

Positive IHC detected in:

human liver cancer tissue, human hepatocirrhosis tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Recommended dilution:
WB : 1:500-1:1000
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
thioredoxin domain containing 12 (endoplasmic reticulum)

Calculated molecular weight:
172 aa, 19 kDa

Observed molecular weight:
20 kDa, 40 kDa

Gene symbol
TXNDC12

Synonyms
AGR1, AIF, AIFM1, ERp18, ERp19, hAG 1, PDCD8, PDIA16, TLP19, TXNDC12

Background

TXNDC12, which is known as thioredoxin domain-containing protein 12, ERp16, ERp18, ERp19, or hTLP19, is a member of the protein disulfide isomerase (PDI) family that plays important roles in cancer development and progression. TXNDC12 has been demonstrated to contribute to tumorigenicity in human gastric cancer by promoting cell growth, migration and invasion(PMID: 25940440). Other study also revealed the overexpression of TXNDC12 promotes HCC metastasis through β-catenin-mediated induction of EMT and that TXNDC12 has the potential to be a prognostic factor and therapeutic target of HCC.(PMID: 31570854)

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