p70(S6K)鼠单克隆抗体

一抗 产品 抗体 3330
p70(S6K)鼠单克隆抗体

p70(S6K)鼠单克隆抗体

  • 价格¥2800
  • 规格200ul
  • 货号HK510141L
  • 单位
  • 品牌HaoKebio

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HaoKebioHK510141Lp70(S6K)鼠单克隆抗体200ul2800

Applications

Tested Applications:

IHC, WB,ELISA


Cited Applications:

WB


Species Specificity:

Human, Mouse, Rat


Cited Species:

human, mouse


Positive WB detected in:

Jurkat cells, HEK-293 cells, HSC-T6 cells, NIH/3T3 cells


Positive IHC detected in:

human lung cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Recommended dilution:

WB : 1:1000-1:6000

IHC : 1:200-1:800

Product Information


Source:

Mouse


Purification method:

Protein G purification


Isotype:

IgG1


Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:

ribosomal protein S6 kinase, 70kDa, polypeptide 1


Calculated molecular weight:

59 kDa


Observed molecular weight:

51-59 kDa


Gene symbol

RPS6KB1


Synonyms

p70 alpha, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K, p70 S6K 1, p70 S6K alpha, p70 S6KA, p70(S6K), p70(S6K) alpha, p70S6K, P70S6K1, PS6K, Ribosomal protein S6 kinase I, RPS6KB1, S6K, S6K beta 1, S6K1, STK14A

Background

RPS6KB1(Ribosomal protein S6 kinase beta-1) is also named as STK14A, p70 S6KA and belongs to the S6 kinase subfamily. RPS6KB1 is a major substrate of MTOR and acts as a crucial effector of MTOR signaling pathway. It plays a key role in cell growth and proliferation by regulating INS sensitivity, metabolism, protein synthesis, and cell cycle. RPS6KB1 may play an important role in the progression of HCC and could serve as a potential molecular target for HCC therapy (PMID:22684641). RPS6KB1 is a 70 kDa protein and has 5 isoforms with the calculated molecular mass of 51-59kDa produced by alternative initiation.

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