GAP43兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK210152M GAP43兔多克隆抗体 100ul 1900
HAOKEBIO HK210152S GAP43兔多克隆抗体 50ul 1200

Applications

Tested Applications:
IHC, IP, WB,ELISA
Cited Applications:
IF, IHC, WB

Species Specificity:
human, mouse, rat

Cited Species:
canine, hamster, mouse, rat

Positive WB detected in:
mouse brain tissue, rat lung tissue, rat brain tissue

Positive IP detected in:
mouse brain tissue

Positive IHC detected in:

mouse brain tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Recommended dilution:
WB : 1:2000-1:10000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
growth associated protein 43

Calculated molecular weight:
238 aa, 25 kDa

Observed molecular weight:
43 kDa

Gene symbol
GAP43

Synonyms
Axonal membrane protein GAP 43, B 50, GAP43, growth associated protein 43, Neural phosphoprotein B 50, Neuromodulin, PP46

Background

The neuronal growth-associated protein GAP43 is also known as neuromodulin, B-50, P-57, F1 and pp46. Deficiency of GAP43 in mice results in death early in the postnatal period. GAP43 is one of the main substrates for protein kinase C in the brain. GAP43 is an intracellular growth-associated protein that appears to assist neuronal pathfinding and branching during development and regeneration, and may contribute to presynaptic membrane changes in the adult, leading to the neurotransmitter release, endocytosis and synaptic vesicle recycling, long-term potentiation, spatial memory formation, and learning. The predicated molecular weight of about 25 kDa is much lower than the apparent observed molecular weight of 43 kDa on SDS-PAGE gels, and this occurs because the highly charged nature of GAP43 causes it to bind less than the average amount of SDS per amino acid, and because the protein has an elongated structure.

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