杭州浩克生物
IL18兔多克隆抗体
324Applications Product Information Immunogen Information Background
查看全文Caspase 1兔多克隆抗体
| 品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
|---|---|---|---|---|---|
| HAOKEBIO | HK210063L | Caspase 1兔多克隆抗体 | 200ul | 支 | 2800 |
| HAOKEBIO | HK210063S | Caspase 1兔多克隆抗体 | 50ul | 支 | 1200 |
Applications
Tested Applications:
IF, IHC, WB, ELISA
Cited Applications:
IF, IHC, WB
Species Specificity:
human, mouse, rat
Cited Species:
bovine, human, monkey, mouse, pig, rat
Positive WB detected in:
RAW264.7, Jurkat cells, Raji cells, MCF-7 cells, HeLa cells, C6 cells, HepG2 cells, NIH/3T3 cells
Positive IHC detected in:
human spleen tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in:
C6 cells
Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:10-1:100
Product Information
Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Immunogen Information
Full name:
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Calculated molecular weight:
404 aa, 45 kDa
Observed molecular weight:
45-47 kDa, 30 kDa, 35 kDa
Gene symbol
CASP1
Synonyms
CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, p10, p20, P45
Background
CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20.
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