Caspase 1兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK210063L Caspase 1兔多克隆抗体 200ul 2800
HAOKEBIO HK210063S Caspase 1兔多克隆抗体 50ul 1200

Applications

Tested Applications:
IF, IHC, WB, ELISA

Cited Applications:
IF, IHC, WB

Species Specificity:
human, mouse, rat

Cited Species:
bovine, human, monkey, mouse, pig, rat

Positive WB detected in:
RAW264.7, Jurkat cells, Raji cells, MCF-7 cells, HeLa cells, C6 cells, HepG2 cells, NIH/3T3 cells

Positive IHC detected in:

human spleen tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
C6 cells

Recommended dilution:
WB : 1:500-1:2000
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)

Calculated molecular weight:
404 aa, 45 kDa

Observed molecular weight:
45-47 kDa, 30 kDa, 35 kDa
Gene symbol
CASP1

Synonyms
CASP 1, CASP1, Caspase 1, Caspase 1/p20/p10, Caspase1, ICE, IL 1 beta converting enzyme, IL 1BC, IL1BC, IL1BCE, p10, p20, P45

Background

CASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20.

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