Cyclin B2兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210119S Cyclin B2兔多克隆抗体 50ul 1200

Applications

Tested Applications:
IHC, IP, WB,ELISA

Cited Applications:
IHC, WB
Species Specificity:
human, mouse, rat

Cited Species:
human

Positive WB detected in:
HeLa cells, DU 145 cells, rat testis tissue, A431 cells, K-562 cells

Positive IP detected in:
A431 cells

Positive IHC detected in:
human cervical cancer tissue, human testis tissue, human colon cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:20-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
cyclin B2

Calculated molecular weight:
398 aa, 45 kDa

Observed molecular weight:
51 kDa

Gene symbol
CCNB2

Synonyms
CCNB2, cyclin B2, G2/mitotic specific cyclin B2, HsT17299

Background

Cyclin B2 (CCNB2) is a member of cyclin family proteins, which regulate the activities of cyclin dependent kinases (CDKs) and different cyclins function spatially and temporally in specific phases of the cell cycle. Cyclin B2 serves a key role in progression of G2/M transition. Cyclin B2 has been found to be up-regulated in a variety of human cancers, such as adrenocortical carcinoma, breast carcinoma, colorectal adenocarcinoma, pituitary adenoma and gastric cancer. The aberrant expression of Cyclin B2 deregulates spindle checkpoints in the cell cycle and results in chromosomal instability (CIN), one of the signature phenotypes of most cancers. Moreover, serum circulating Cyclin B2 mRNA expression has been found increased in cancer patients and associated with cancer stage and metastasis status.

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