| 产品名称 | Collagen Type I Recombinant antibody |
|---|---|
| 产品编号 | HB50322 |
| 发货周期 | 现货 |
| Uniprot ID | P02452 |
| Host Species | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Tested Applications | IHC |
| Application | IHC :1:100 -1:200，IHC-Polymer:1:400-1:800，TSA:1:1000-1:2000 |
| Background | Type I collagen, the major structural component of connective tissues such as skin, tendon and bone, is the most abundant and widely expressed collagen in humans (PMID: 7620364; 8645190; 9016532). Type I collagen is a heterotrimer comprising one alpha 2(I) and two alpha 1(I) chains which are encoded by the unlinked loci COL1A2 and COL1A1 respectively. Mutations in COL1A1 are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. This antibody raised against a synthesized peptide corresponding to 1206-1218 aa of human pro-alpha 1 chain of type I collagen recognize collagen alpha-1(I) chain. The presence of unprocessed, intermediate, and mature chains of type I collagen was clearly detected only in static constructs. Indeed, in sponges cultured under perfusion the presence of type I collagen was mainly restricted to mature chains, suggesting that HACs were no longer actively producing type I collagen (PMID: 27584727). It is reported that the molecular weight is 200kDa(PMID: 28526934). |
| Alternative Names | COL1A1, 1E9A7, Alpha 1 type I collagen, Alpha-1 type I collagen, COL I |
| Immunogen | Peptide |
| Calculated MW | 139 kDa |
| Subcellular Localization | Extracellular matrix |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Purification | Protein A affinity purified |
| Storage Buffer | PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%. |
| Formulation | Liquid |
| Storage | Store at -20°C |
| 保质期 | 12 months |
