AI兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210005M AI兔多克隆抗体 100ul 1960
KAOKEBIO HK210005L AI兔多克隆抗体 200ul 2800

Applications

Tested Applications:
IF, IHC, IP, WB,ELISA

Cited Applications:
IF, IHC, WB
Species Specificity:
human, mouse, rat

Cited Species:
human, mouse, rat, sheep

Positive WB detected in:
HeLa cells, Jurkat cells, A549 cells, rat kidney tissue, NIH/3T3 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:

human kidney tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
HepG2 cells

Recommended dilution:
WB : 1:1000-1:8000
IP : 0.5-4.0 ug for IP and 1:1000-1:4000 for WB
IHC : 1:100-1:400
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
apoptosis-inducing factor, mitochondrion-associated, 1

Calculated molecular weight:
609 aa, 66 kDa

Observed molecular weight:
67 kDa, 57 kDa

Gene symbol
AIFM1

Synonyms
AIF, AIFM1, PDCD8

Background

Apoptosis-inducing factor (AIF) is one of the mitochondrial proteins to be released into the cytosol during apoptosis, and it is discovered as the first protein that regulates caspase-independent apoptosis(PMID:20494118). AIF is encoded as a 67 kDa protein that contains a mitochondrial localization signal (MLS) in the N-terminus.It is cleaved from the 62 kDa to the 57 kDa form following ischemic injury and translocated from the mitochondria to the nucleus in a calpain-dependent manner(PMID:19332058).

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