品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKI0621A	甲状腺转录因子-1TTF-1兔单克隆抗体	100ul	支	1650

Applications

Tested Applications:

IHC, WB,ELISA

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Cited Applications:

WB

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Species Specificity:

human, pig

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Cited Species:

human

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Positive WB detected in:

HepG2 cells

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Positive IHC detected in:

human thyroid cancer tissue, human lung cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

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Recommended dilution:

WB : 1:1000-1:8000

IHC : 1:50-1:500

Product Information

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Source:

Mouse

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Purification method:

Protein A purification

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Isotype:

IgG3

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Immunogen Information

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Immunogen:

Peptide

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Full name:

NK2 homeobox 1

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Calculated molecular weight:

42 kDa

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Observed molecular weight:

41 kDa

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Gene symbol

NKX2-1

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Synonyms

BHC, Homeobox protein Nkx 2.1, NK 2, NK2 homeobox 1, NKX2 1, NKX2.1, NKX2-1, NKX2A, TEBP, Thyroid nuclear factor 1, Thyroid transcription factor 1, TITF1, TTF 1, TTF1

Background

Homeobox protein Nkx-2.1 (NKX2-1), also named Thyroid nuclear factor 1,Thyroid transcription factor 1(TTF1). It is a transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Defects in NKX2-1 are the cause of benign hereditary chorea (BHC), choreoathetosis, hypothyroidism, and neonatal respiratory distress (CHNRD)

Protocols

PRODUCT