GranzymeB兔单克隆抗体

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GranzymeB兔单克隆抗体

GranzymeB兔单克隆抗体

human thyroid cancer tissue, human lung cancer tissue
  • 价格¥10500
  • 规格1ml
  • 货号HKI0291B
  • 单位
  • 品牌HaoKebio

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HaoKebioHKI0291BGranzymeB兔单克隆抗体1ml10500

Applications

Tested Applications:

FC, IF, IHC, WB,ELISA


Cited Applications:

IF, IHC, WB


Species Specificity:

human


Cited Species:

human, mouse


Positive WB detected in:

HL-60 cells


Positive IHC detected in:

human lymphoma tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:

HeLa cells


Positive FC detected in:

HeLa cells


Recommended dilution:

WB : 1:500-1:2000

IHC : 1:50-1:500

IF : 1:50-1:500

Product Information


Source:

Rabbit


Purification method:

Antigen affinity purification


Isotype:

IgG


Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:

granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)


Calculated molecular weight:

247 aa, 28 kDa


Observed molecular weight:

33 kDa


Gene symbol

GZMB


Synonyms

CCPI, CGL 1, CGL1, CSP B, CSPB, CTLA1, CTSGL1, Endogenous granzyme B, Granzyme B, GZMB, HLP, SECT

Background

GZMB(Granzyme B) is also named as CGL1, CSPB, CTLA1, GRB and belongs to the Granzyme subfamily. This enzyme is necessary for target cell lysis in cell-mediated immune responses. The cytotoxic lymphocyte protease granzyme B (GzmB) can promote apoptosis through direct processing and activation of members of the caspase family. GzmB can also cleave the BH3-only protein, BID, to promote caspase-independent mitochondrial permeabilization (PMID:17283187). GzmB induces laminB degradation in isolated nuclei less efficiently than GzmA (PMID:11331782). This full length protein has 2 glycosylation sites and a signal peptide. Unglycosylated human granzyme B is 26 kDa and g high mannose glycosylated is 32 kDa and only 32kDa or smaller forms of granzyme B are accumulated within nuclei (PMID:8626751).

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