品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKI0591B	COX-2兔单克隆抗体	1ml	支	5512.5

Applications

Tested Applications:

IF, IHC, WB, ELISA

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Cited Applications:

IF, IHC, WB

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Species Specificity:

human, mouse

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Cited Species:

human, mouse, rat

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Positive WB detected in:

A549 cells, mouse lung tissue

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Positive IHC detected in:

human lung tissue, human spleen tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

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Positive IF detected in:

mouse lung tissue

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Recommended dilution:

WB : 1:500-1:1000

IHC : 1:100-1:400

IF : 1:50-1:500

Product Information

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Source:

Rabbit

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Purification method:

Antigen affinity purification

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Isotype:

IgG

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Immunogen Information

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Full name:

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

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Calculated molecular weight:

604 aa, 68 kDa

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Observed molecular weight:

69 kDa

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Gene symbol

PTGS2

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Synonyms

COX 2, COX2, COX2/ Cyclooxygenase 2, COX2/ Cyclooxygenase 2/ PTGS2, Cyclooxygenase 2, GRIPGHS, hCox 2, PGG/HS, PGH synthase 2, PGHS 2, PHS 2, PHS II, Prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, PTGS2

Background

COX2 (Prostaglandin G/H synthase 2, PTGS2) mediates the formation of prostaglandins from arachidonate. Its subunit structure is homodimer. The fully N-glycosylated PTGS2 is 72-74 kDa and the aglycosylated is 66 kDa(PMID:19656660 ). It also expresses a band of 39 kDa after unspecific cleavage(PMID:17509125 ). The 50 kDa band of fragmented PTGS2 has also previously been detected in AD brains(PMID:14724276 ).