品牌	商品编码	商品名称	规格	单位	单价
HaoKebio	HKI0661B	NapsinA兔单克隆抗体	1ml	支	10106.25

Applications

Tested Applications:

IF, IHC, WB,ELISA

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Species Specificity:

human, mouse

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Positive WB detected in:

mouse lung tissue

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Positive IHC detected in:

human lung cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

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Positive IF detected in:

PC-3 cells

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Recommended dilution:

WB : 1:500-1:1000

IHC : 1:50-1:500

IF : 1:10-1:100

Product Information

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Source:

Rabbit

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Purification method:

Antigen affinity purification

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Isotype:

IgG

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Storage:

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20^oC storage.

Immunogen Information

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Full name:

napsin A aspartic peptidase

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Calculated molecular weight:

420 aa, 45 kDa

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Observed molecular weight:

45-55 kDa

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Gene symbol

NAPSA

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Synonyms

Asp 4, ASP4, Aspartyl protease 4, KAP, Kdap, NAP1, NAPA, NAPSA, Napsin 1, Napsin A, napsin A aspartic peptidase, Pronapsin A, SNAPA, TA01/TA02

Background

Napsin is found in two isoforms, napsin A and B, with highly homologous nucleotide sequences (91.2%). Napsin A appears to be a functional proteinase, predominantly expressed in lung and kidney. Napsin B is transcribed exclusively in cells related to the immune system and lacks an in-frame stop codon and is believed to be a pseudogene.(PMID:12698189). Napsin A is superior to TTF-1 in distinguishing primary lung ACA from other carcinomas (except kidney), particularly primary lung small cell carcinoma, and primary thyroid carcinoma.(PMID:22288963).