FIS1兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK210146L FIS1兔多克隆抗体 200ul 2800
HAOKEBIO HK210146S FIS1兔多克隆抗体 50ul 1200

Applications

Applications

Tested Applications:
IF, IHC, IP, WB, ELISA

Cited Applications:
CoIP, IF, IHC, IP, WB
Species Specificity:
human, mouse, rat, pig

Cited Species:
bovine, Chinese hamster ovary (CHO) cell, hamster, human, mouse, pig, rat, squirrel

Positive WB detected in:
HeLa cells, SH-SY5Y cells, pig brain tissue, rat brain tissue, mouse heart tissue, rat heart tissue, mouse brain tissue, Jurkat cells, mouse spleen, rat spleen

Positive IP detected in:
HeLa cells

Positive IHC detected in:

rat brain tissue, human brain tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
Hepa1-6 cells, HepG2 cells

Recommended dilution:
WB : 1:500-1:3000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:200

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)

Calculated molecular weight:
17 kDa

Observed molecular weight:
17 kDa

Gene symbol
FIS1

Synonyms
CGI 135, FIS1, FIS1 homolog, hFis1, TPR repeat protein 11, TTC11

Background

Fis1 (fission 1) is an integral mitochondrial outer membrane protein that participates in mitochondrial fission by interacting with dynamin-related protein 1 (Drp1). Excessive mitochondrial fission is associated with the pathology of a number of neurodegenerative or neurodevelopmental diseases. Increased expression of Fis1 has been found in Huntington's disease (HD)-affected brain, Alzheimer's disease (AD) patients, and autism spectrum disorder. This antibody was raised against the full-length of human Fis1 protein, and recognizes endogenous Fis1 protein in various lysates. (PMID: 21257639, 21459773, 23333625)

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