| 产品名称 | 53BP1 Recombinant antibody |
|---|---|
| 产品编号 | HB10017 |
| Uniprot ID | Q12888 |
| Host Species | Rabbit |
| Reactivity | Human |
| Tested Applications | WB, IHC-P, ICC/IF |
| Application | WB: 1:5000-1:50000 IHC-P: 1:50-1:100 ICC/IF: 1:100-1:200 |
| Background | This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017] |
| Alternative Names | TP53; p202; 53BP1; TDRD30; p53BP1 |
| Immunogen | A synthetic peptide of human 53BP1 |
| Calculated MW | 214 kDa |
| Observed mw | 450 kDa |
| Subcellular Localization | nucleus |
| Isotype | IgG |
| Conjugate | Unconjugated |
| Purification | Affinity Purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| Formulation | Liquid |
| Storage | Store at -20°C |
| 曾用货号 | B35012D |
| 保质期 | 12 months |
