TROP-2兔单克隆抗体

TROP-2兔单克隆抗体

  • 价格¥2200
  • 规格100ul
  • 货号HKZ150231
  • 单位
  • 品牌HaoKebio

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HaoKebioHKZ150231TROP-2兔单克隆抗体100ul2200
TROP-2
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog#  HKZ150231 Clone#  BP6208
Predicted Molecular Wt:
36kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P09758
Background:
TROP-2 or Tumor-associated calcium signal transducer 2, also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. This transmembrane glycoprotein functions in a variety of cell signaling
pathways and was first elucidated as a transducer of an intracellular calcium signal..
TROP-2 is expressed in a variety of epithelial tissues and tumor tissues from which TROP2 originates, such as tonsil, esophagus, pancreatic, prostate and gastric cancers.
TROP-2 has become a new target for researchers to develop antibody-conjugated drugs. TROP-2 is highly expressed in triple-  negative breast cancer, non-small cell lung cancer, uroepithelial carcinoma and various types of solid tumors, and is expected
Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer
(pH 9.0), primary antibody incubate at RT (18°C-25°C)
for 30 minutes.
Immunogen:
Synthetic peptide. This information is proprietary to Biolynx.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA
0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store
at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1.  McDougall, A.R. et al. (2015) Dev Dyn 244, 99-109.
2. Shvartsur, A. and Bonavida, B. (2015) Genes Cancer 6, 84-105.
Immunohistochemistry
(Formalin/PFA-fixed paraffin-
embedded sections) analysis of
human esophageal carcinoma
tissue labelling TROP-2 with
BP6208. Heat mediated antigen retrieval was performed using    Tris/EDTA buffer pH 9.0

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