ALK兔单克隆抗体

ALK兔单克隆抗体

  • 价格¥1000
  • 规格100ul
  • 货号HKZ150187
  • 单位
  • 品牌HaoKebio

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HaoKebioHKZ150187ALK兔单克隆抗体100ul1000
ALK
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog#  HKZ150187 Clone#  BP6165
Predicted Molecular Wt:
177kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:  Q9UM73
Background:
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase of the insulin receptor superfamily. ALK is typically expressed at low levels in regions of the developing central and peripheral nervous system.
ALK may be activated in cancer through multiple mechanisms. The most common mechanism is through formation of a fusion
protein from chromosomal translocations, as in the case of anaplastic large cell lymphoma (ALCL) and inflammatory
myofibroblastic tumors. ALK may also be amplified through mutation, as in neuroblastomas. Various solid tumors, such as non-small cell lung carcinoma (NSCLC) and brain cancers were also found to aberrantly express ALK.
ALK staining is present within both the nucleus and cytoplasm, and are positive in about 60% of ALCL. ALK protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome.
Subcellular location:
Cytoplasm&Nucleus
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Recombinant protein of Human ALK was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Zhu W  etal. Transl Stroke Res (2018).
2. Yang Y  et al. Biol Open 8: (2019).
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections) analysis
of  human non-small cell lung carcinoma tissue
labelling ALK with
BP6165. Heat mediated antigen retrieval was
performed using
Tris/EDTA buffer pH 9.0

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