RRM1兔单克隆抗体

RRM1兔单克隆抗体

  • 价格¥2200
  • 规格100ul
  • 货号HKZ150118
  • 单位
  • 品牌HaoKebio

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品牌商品编码商品名称规格单位单价
HaoKebioHKZ150118RRM1兔单克隆抗体100ul2200
RRM1
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog#  HKZ150118 Clone#  BP6122
Predicted Molecular Wt:
90kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P23921
Background:
Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate
reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It
provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in  quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.
Subcellular location:
Cytoplasmic
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to residues within aa700-800 of  Human RRM1 was used as an
immunogen.
Storage Buffer:
0.05%.                                                                                       
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Wang,Q, et al. PLoS ONE. 2013 Jul;8(7):1-12.
2.   Nordlund P, et al. Annu Rev Biochem. 2006; 75:681–706.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections) analysis of
breast carcinoma tissue labelling RRM1 with
BP6122. Heat mediated antigen retrieval was
performed using
Tris/EDTA buffer pH 9.0

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