Thyroglobulin兔单克隆抗体

Thyroglobulin兔单克隆抗体

  • 价格¥600
  • 规格100ul
  • 货号HKZ150062
  • 单位
  • 品牌HaoKebio

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HaoKebioHKZ150062Thyroglobulin兔单克隆抗体100ul600
Thyroglobulin
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog#  HKZ150062 Clone#  BP6067
Predicted Molecular Wt:
305kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P01266
Background:
Thyroglobulin (TG) is a dimeric glycoprotein specific to the thyroid gland which belongs to the type-B carboxylesterase/lipase family. It is the precursor of the iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4). Variations in TG are
associated with susceptibility to autoimmune thyroid disease type 3. Defective or impaired TG synthesis usually results in
congenital goitrous hypothyroidism, virtual absence of TG in thyroid tissue, and the presence of an elevated concentration of iodoalbumin. The final result of these abnormalities is a decreased rate of T3 and T4 synthesis.
Thyroglobulin is found in normal thyroid and differentiated thyroid carcinoma cells, but not undifferentiated thyroid. It is a useful marker for identification of tumors with thyroid origin.
 Subcellular location:
Cytoplasm
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
Synthetic peptide corresponding to Thyroglobulin
residues within aa350-450 of  Thyroglobulin was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Abrosimov A et al. Arkh Patol. 1996 Jul;58(4):43-8.
2.  Pastolero GC et al. Am J Surg Pathol. 1996 Feb;20(2):245-50.
Immunohistochemistry (Formalin/PFA-fixedparaffin-embedded
sections analysis of
thyroid cancer tissue
labelling thyroglobulin with BP6067. Heat
mediated antigen
retrieval was performed using Tris/EDTA buffer    pH 9.0

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