CD10兔单克隆抗体

CD10兔单克隆抗体

  • 价格¥1000
  • 规格100ul
  • 货号HKZ150054
  • 单位
  • 品牌HaoKebio

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HaoKebioHKZ150054CD10兔单克隆抗体100ul1000
CD10
Recombinant Rabbit Monoclonal Antibody Product Datasheet
Catalog# HKZ150054 Clone#  BP6059
Predicted Molecular Wt:
86kDa
Purity:   ProA affinity purified IgG
Species Cross-reactivity:
Human
Form:   Liquid
Applications:
IHC-P
Swissprot ID:   P08473
Background:
CD10 is a single-chain cell surface glycoprotein, also is designated as common acute lymphoblastic leukaemia antigen (CALLA), neprilysin and neutral endopeptidase. Besides, CD10 is a zink-dependent peptidase (metalloprotease),degrading various
bioactive peptides, and it plays a functional role by modulating cellular responses to peptide substrates.
CD10 is present on the cell surface of bone marrow stem cells and myelopoietic cells (including neutrophils),follicular centre cells, few mature B-lymphocytes, and a subpopulation of parafollicular T-lymphocytes. CD10 is also found in enterocytes in    the upper part of the intestinal tract (brush border),in liver (bile canaliculi), kidney (glomerular and proximal tubular cells),    pulmonary alveolar cells, myoepithelial cells of breast and sweat and salivary glands, prostate glandular cells, placental
trophoblastic cells, endometrial stromal cells, some endothelial cells, and a minority of (myo-)fibroblasts (including skin    periadnexal cells). CD10 is expressed in a high percentage of cases of acute lymphoblastic leukemia, follicular lymphoma, Burkitt’s lymphoma, some hematopoietic tumors, and chronic myelogenous leukemias in lymphoid blast crisis.
CD10 is particularly useful in the classification of B-cell leukaemias/lymphomas and classification of carcinomas (identification
of hepatocellular carcinoma and renal cell carcinoma). CD10 may be used in the identification of metaplastic breast
carcinoma, prognostication of breast carcinoma, and classification of uterine mesenchymal neoplasms (identification of stromal sarcoma).
Subcellular location:
Membrane
Recommended method:
Heat induced epitope retrieval with Tris-EDTA buffer   (pH 9.0), primary antibody incubate at RT (18°C-25°C) for 30 minutes.
Immunogen:
A recombinant protein corresponding to CD10 residues within aa1-500 was used as an immunogen.
Storage Buffer:
PBS 59%, Sodium azide 0.01%, Glycerol 40%, BSA 0.05%.
Storage conditions:
-25°C to -18°C
Storage instructions:
Shipped on blue ice. Upon delivery, aliquot, and store at -25°C to -18°C. Avoid freeze / thaw cycles.
Recommended Dilutions:
IHC-P:     1:100-1:200
Background References:
1. Chu P, et al. Am J Clin Pathol 2000 Mar;113(3):374-82.
2.  Iwaya K,et al. Virchows Arch 2002 Jun;440(6):589-93.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded
sections analysis of tonsil tissue labelling CD10
with BP6059. Heat mediated antigen
retrieval was performed using Tris/EDTA buffer    pH 9.0

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