MPO抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK66177 MPO抗体 100ul 3100

Applications

Tested Applications:
IF, IHC, IP, WB,ELISA

Cited Applications:
FC, IF, IHC, WB
Species Specificity:
human, mouse

Cited Species:
human, rat

Positive WB detected in:
HeLa cells, MCF-7 cells, U-937 cells

Positive IP detected in:
HeLa cells

Positive IHC detected in:

human colon cancer tissue, mouse colon tissue, human liver tissue, human spleen tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
human tonsillitis tissue

Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
myeloperoxidase

Calculated molecular weight:
745 aa, 84 kDa

Observed molecular weight:
59 kDa

Gene symbol
MPO

Synonyms
MPO, myeloperoxidase

Background

The MPO gene encodes myeloperoxidase, a lysosomal hemoprotein located in the azurophilic granules of polymorphonuclear (PMN) leukocytes and monocytes. In response to stimulation, MPO is activated into a transient intermediate with potent antimicrobial oxidizing abilities(PMID:17650507). The mRNA is translated into a single protein of 90 kDa, which displays enzymatic activity and undergoes proteolytic maturation into a heavy chain of 59 kDa and a light chain of 13.5 kDa; these subunits then dimerize into the mature tetramer and the mature MPO is a heterotetramer composed of two identical heavy chains and two identical light chains(PMID:12773517). The 24-kDa material had a map identical to that of 13.5 kDa subunit and represents a dimer of the 13.5 kDa subunit (PMID:3008892). Defects in MPO are the cause of myeloperoxidase deficiency (MPOD). It has 3 isoforms produced by alternative splicing. This antibody is specific to MPO

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