CD31兔单克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HKI0351A CD31兔单克隆抗体 100ul 1313

Applications

Tested Applications:
IF, IHC, WB, ELISA

Cited Applications:
IF, IHC, WB
Species Specificity:
Human

Cited Species:
human

Positive WB detected in:
human peripheral blood platelets, Jurkat cells, THP-1 cells

Positive IHC detected in:

human liver cancer tissue, human breast cancer tissue, human tonsillitis tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
human liver cancer tissue

Recommended dilution:
WB : 1:5000-1:50000
IHC : 1:5000-1:20000
IF : 1:200-1:800

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG1

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Aliquoting is unnecessary for -20oC storage.

Full name:
platelet/endothelial cell adhesion molecule

Calculated molecular weight:
83 kDa

Observed molecular weight:
120-130 kDa

Gene symbol
PECAM1

Synonyms
CD31, EndoCAM, FLJ58394, GPIIA, PECA1, PECAM 1, PECAM1, VEC marker

Background

Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489)

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