CD13鼠单克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK510044L CD13鼠单克隆抗体 200ul 2800

Applications

Tested Applications:
FC, IF, IHC, WB,ELISA

Cited Applications:
IF, IHC, WB

Species Specificity:
human

Cited Species:
human

Positive WB detected in:
U-937 cells

Positive IHC detected in:

human tonsillitis tissue, human kidney tissue, mouse kidney tissue, rat kidney tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
human kidney tissue

Positive FC detected in:
U-937 cells

Recommended dilution:
WB : 1:3000-1:8000
IHC : 1:5000-1:20000
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2a

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
alanyl (membrane) aminopeptidase

Calculated molecular weight:
110 kDa

Observed molecular weight:
150 kDa

Gene symbol
ANPEP

Synonyms
Alanyl aminopeptidase, Aminopeptidase M, Aminopeptidase N, ANPEP, AP M, AP N, APN, CD13, gp150, hAPN, LAP1, Microsomal aminopeptidase, p150, PEPN

Background

CD13, also named as APN, ANPEP(aminopeptidase N) or PEPN, is belongs to the peptidase M-1 family. CD13 is a heavily glycosylated, ~150-240 kDa, type-II membrane, expressed by most cells of myeloid origin including monocytes, macrophages, granulocytes, and their hematopoietic precursors. It is also abundantly expressed in the brush border of epithelial cells from renal proximal tubules and small intestine, in prostatic epithelial cells, in bile duct canaliculi, in mast cells, and, in some cases, in fibroblasts and smooth muscle cells. CD13 is a multifunctional protein and plays varying roles in cell migration, cell proliferation, cell differentiation and so on. CD13 participates in angiogenesis generating and modulating angiogenic signals, and can be a marker of angiogenic vessels. CD13 is also a pan-myeloid marker, present on mature granulocytes and monocytes. (PMID: 8805662, 10098327, 18603472, 18097955, 17897790, 17888402, 21339174)

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