BCL2鼠单克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK510021L BCL2鼠单克隆抗体 200ul 2800

Applications

Tested Applications:
FC, IF, IHC, IP, WB,ELISA

Cited Applications:
CoIP, IF, IHC, WB
Species Specificity:
human, pig

Cited Species:
human, pig, rat

Positive WB detected in:
U2OS cells, U-937 cells, Jurkat cells, pig spleen tissue, THP-1 cells, HepG2 cells, HEK-293 cells, HT-1080 cells, MCF-7 cells, Raji cells

Positive IP detected in:
U-937 cells

Positive IHC detected in:

human appendicitis tissue, human tonsillitis tissue, human lymphoma tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
MCF-7 cells, human tonsillitis tissue

Positive FC detected in:
human peripheral blood lymphocytes, Jurkat cells

Recommended dilution:
WB : 1:2000-1:10000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:6400-1:25600
IF : 1:50-1:500

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
B-cell CLL/lymphoma 2

Calculated molecular weight:
26 kDa

Observed molecular weight:
26 kDa

Gene symbol
BCL2

Synonyms
Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, BCL-2, Oncogene B cell leukemia 2

Background

BCL2 belongs to the Bcl-2 family. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. BCL2 regulates cell death by controlling the mitochondrial membrane permeability. It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).

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