BAX鼠单克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK510016L BAX鼠单克隆抗体 200ul 2800

Applications

Tested Applications:
FC, IHC, WB,ELISA

Cited Applications:
CoIP, IF, IHC, WB

Species Specificity:
human, mouse, rat

Cited Species:
human, mouse, pig, rat

Positive WB detected in:
HeLa cells, human testis tissue, HEK-293 cells, COLO 320 cells, PC-12 cells, ROS1728 cells, Neuro-2a cells

Positive IHC detected in:

human liver cancer tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:5000-1:20000
IHC : 1:500-1:2000

Product Information


Source:
Mouse

Purification method:
Protein A purification

Isotype:
IgG2b

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-associated X protein

Calculated molecular weight:
21 kDa

Observed molecular weight:
21 kDa

Gene symbol
BAX

Synonyms
Apoptosis regulator BAX, BAX

Background

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579).

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