ZO-1兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK210363S ZO-1兔多克隆抗体 50ul 1200

Applications

Tested Applications:
FC, IF, IP, WB,ELISA

Cited Applications:
FC, IF, WB

Species Specificity:
human, Canine, mouse, rat, hamster

Cited Species:
bovine, canine, chicken, human, mouse, pig, rat

Positive WB detected in:
MCF-7 cells, COLO 320 cells, A431 cells, HEK-293 cells, HepG2 cells

Positive IP detected in:
HEK-293 cells

Positive IF detected in:
HUVEC cells, MDCK cells, CHO cells

Positive FC detected in:
MCF-7 cells

Recommended dilution:
WB : 1:1000-1:10000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IF : 1:1000-1:4000

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
tight junction protein 1 (zona occludens 1)

Calculated molecular weight:
1748 aa, 195 kDa

Observed molecular weight:
230 kDa

Gene symbol
TJP1

Synonyms
Tight junction protein 1, Tight junction protein ZO 1, TJP1, ZO 1, ZO1, ZO-1, Zona occludens protein 1, Zonula occludens protein 1

Background

Tight junction (or zonula occludens) form the continuous intercellular barrier between epithelial and endothelial cells, which is required to separate tissue spaces and regulate selective movement of solutes across the epithelium and endothelium (PMID: 20066090). ZO-1 (also known as TJP1) is a peripheral membrane phosphoprotein located on the cytoplasmic face and is expressed in tight junctions of both epithelial and endothelial cells (PMID: 3528172). It binds the transmembrane proteins occludin and the claudins linking them to cytoskeletal actin (PMID: 17418867). ZO-1 belongs to a family of multidomain proteins known as the membrane-associated guanylate kinase homologs (MAGUKs). It is a pivotal tight junction protein and may be involved in signalling mechanisms regulating cell proliferation and differentiation (PMID: 22782886).

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