Caspase 4兔多克隆抗体
137Applications Product Information Immunogen Information Background
查看全文品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
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HAOKEBIO | HK210272S | PAX8兔多克隆抗体 | 50ul | 支 | 1200 |
human ovary tumor tissue, human thyroid cancer tissue, human renal cell carcinoma tissue, mouse kidney tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
PAX8 is a member of the paired box (PAX) family of transcription factors, typically containing a paired box domain and a paired-type homeodomain. It is expressed during organogenesis of the thyroid gland, kidney and Mullerian system. It is thought to regulate the expression of Wilms tumor suppressor (WT1) gene and mutations in PAX8 have been associated with Wilms tumor cells, thyroid and ovarian carcinomas. PAX8 is a useful marker in distinguishing ovarian carcinomas from mammary carcinomas (PMID: 18724243). PAX8 is expressed in a high percentage of ovarian serous, endometrioid, and clear cell carcinomas, but only rarely in primary ovarian mucinous adenocarcinomas.
This antibody can detect all 5 isoforms of PAX8 (31 kDa, 34 kDa, 41 kDa, 43 kDa and 48 kDa). A 58-60 kDa form has also been reported (PMID:15650356, 1049952). Proteintech’s 10336-1-AP antibody has cross-reactivities with the other PAX family members.
Applications Product Information Immunogen Information Background
查看全文Tested Applications: IF, IHC, WB,ELISA Cited Applications: IF, WB Species Specificity: human, Canine...
查看全文Tested Applications: WB, ELISA Cited Applications: WB Species Specificity: human Cited Species: human Pos...
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