杭州浩克生物
ODF2兔多克隆抗体
2品牌 商品编码 商品名称 规格 单位 单价 HAOKEBIO HK210256M ODF2兔多克隆抗体 100ul 支 1960 Applications Tested Applications: IF, IHC, IP, WB, ELISA Cited App...
详情咨询MCL1兔多克隆抗体
| 品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
|---|---|---|---|---|---|
| HAOKEBIO | HK210212L | MCL1兔多克隆抗体 | 200ul | 支 | 2800 |
Applications
Tested Applications:
IF, IHC, IP, WB,ELISA
Cited Applications:
IF, IHC, IP, WB
Species Specificity:
human, mouse, rat
Cited Species:
human, mouse, rat
Positive WB detected in:
Jurkat cells, K-562 cells, human liver tissue, human brain tissue, HEK-293T cells, A431 cells, mouse spleen tissue, Raji cells, HL-60 cells, MCF-7 cells, HeLa cells
Positive IP detected in:
Raji cells
Positive IHC detected in:
human tonsillitis tissue, human cervical cancer tissue, human lung cancer tissue, human pancreas tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
Positive IF detected in:
MCF-7 cells
Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500
Product Information
Source:
Rabbit
Purification method:
Antigen affinity purification
Isotype:
IgG
Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.
Full name:
myeloid cell leukemia sequence 1 (BCL2-related)
Calculated molecular weight:
350 aa, 37 kDa
Observed molecular weight:
35-40 kDa
Gene symbol
MCL1
Synonyms
EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM
Background
MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. MCL-1 can be alternatively spliced into a long form (MCL-1L, 40 kDa) or a short form (MCL-1S, 30 kDa). (PMID: 15467463, PMID: 15147382)
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