MCL1兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK210212L MCL1兔多克隆抗体 200ul 2800

Applications

Tested Applications:
IF, IHC, IP, WB,ELISA

Cited Applications:
IF, IHC, IP, WB

Species Specificity:
human, mouse, rat

Cited Species:
human, mouse, rat

Positive WB detected in:
Jurkat cells, K-562 cells, human liver tissue, human brain tissue, HEK-293T cells, A431 cells, mouse spleen tissue, Raji cells, HL-60 cells, MCF-7 cells, HeLa cells

Positive IP detected in:
Raji cells

Positive IHC detected in:

human tonsillitis tissue, human cervical cancer tissue, human lung cancer tissue, human pancreas tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
MCF-7 cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Full name:
myeloid cell leukemia sequence 1 (BCL2-related)

Calculated molecular weight:
350 aa, 37 kDa

Observed molecular weight:
35-40 kDa

Gene symbol
MCL1

Synonyms
EAT, Mcl 1, Mcl 1l, Mcl 1s Delta TM, MCL1, mcl1/EAT, MCL1L, MCL1S, TM

Background

MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. MCL-1 can be alternatively spliced into a long form (MCL-1L, 40 kDa) or a short form (MCL-1S, 30 kDa). (PMID: 15467463, PMID: 15147382)

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