CD7兔单克隆抗体
177Applications Product Information Immunogen Information Background human tonsillitis tissue, human lung cancer tissue Note: sugg...
查看全文品牌 | 商品编码 | 商品名称 | 规格 | 单位 | 单价 |
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HAOKEBIO | HK210212L | MCL1兔多克隆抗体 | 200ul | 支 | 2800 |
human tonsillitis tissue, human cervical cancer tissue, human lung cancer tissue, human pancreas tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0
MCL-1 is an anti-apoptotic member of the Bcl-2 family originally isolated from the ML-1 human myeloid leukemia cell line. Similar to BCL2 and BCL2L1, MCL1 can interact with BAX and/or BAK1 to inhibit mitochondria-mediated apoptosis. Mcl-1 is critical for the proliferation and survival of myeloma cells in vitro, and overexpression of Mcl-1 protein in myeloma cells is associated with relapse and short event-free survival in multiple myeloma patients. Recent studies show that MCL-1 is upregulated in numerous haematological and solid tumour malignancies. Therefore, MCL-1 has been suggested as a potential new therapeutic target. MCL-1 can be alternatively spliced into a long form (MCL-1L, 40 kDa) or a short form (MCL-1S, 30 kDa). (PMID: 15467463, PMID: 15147382)
Tested Applications: IF, IHC, WB, ELISA Cited Applications: ELISA, IF, IHC, WB Species Specificity: ...
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