LKB1兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
HAOKEBIO HK210208L LKB1兔多克隆抗体 200ul 2800

Applications

Tested Applications:
IHC, IP, WB,ELISA

Cited Applications:
CoIP, IF, IHC, IP, WB
Species Specificity:
human, mouse, rat

Cited Species:
human, mouse, rat

Positive WB detected in:
HeLa cells, HepG2 cells

Positive IP detected in:
HEK-293 cells

Positive IHC detected in:

human lung cancer tissue, human breast cancer tissue, human testis tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Recommended dilution:
WB : 1:500-1:1000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information

Full name:
serine/threonine kinase 11

Calculated molecular weight:
49 kDa

Observed molecular weight:
54 kDa

Gene symbol
STK11

Synonyms
LKB1, PJS, serine/threonine kinase 11, STK11

Background

STK11(serine/threonine-protein kinase 11) is also named as LKB1, PJS, and belongs to the protein kinase superfamily. It controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. The tumour suppressor protein LKB1 is a serine/threonine kinase that has been causally linked to Peutz-Jeghers syndrome (PJS). Defects in STK11 are a cause of Peutz-Jeghers syndrome (PJS) and defects in STK11 have been associated with testicular germ cell tumor (TGCT) and some sporadic cancers, especially lung cancers. STK11 has 2 isoforms with MW of 49 kDa and 45 kDa, and can be detected as 50-54 kDa after posttranslational modification.

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