BAX兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210032L BAX兔多克隆抗体 200ul 2800
KAOKEBIO HK210032M BAX兔多克隆抗体 100ul 1960

Applications

Tested Applications:
FC, IP, WB,ELISA
Cited Applications:
chIP, CoIP, FC, IHC, IP, WB
Species Specificity:
human, mouse, rat

Cited Species:
Astragalus membranaceus, bovine, canine, chicken, goat, hamster, Hu Sheep, human, mouse, pig

Positive WB detected in:
HT-1080 cells, RAW 264.7 cells, HeLa cells, HEK-293 cells, mouse kidney tissue, rat kidney tissue, COLO 320 cells, Raji cells, rat lung tissue, PC-12 cells

Positive IP detected in:
Raji cells

Positive FC detected in:
Raji cells, HeLa cells

Recommended dilution:
WB : 1:5000-1:12000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB

Product Information


Source:
Rabbit

Purification method:
Protein A purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-associated X protein

Calculated molecular weight:
21 kDa

Observed molecular weight:
21 kDa

Gene symbol
BAX

Synonyms
Apoptosis regulator BAX, BAX

Background

BAX, also named as BCL2L4, is a pro-apoptotic member of the Bcl-2 protein family, which plays a pivotal role in controlling cell life and death. Bax largely localizes to the cytoplasm of healthy cells, but accumulates on the outer mitochondrial membrane upon apoptosis induction (PMID: 9108035). BAX can commit a cell to apoptosis by translocation from the cytosol to the mitochondria and permeabilization of the outer mitochondrial membrane, which leads to the release of cytochrome c from mitochondria (PMID: 21763611). The expression of BAX is upregulated by the tumor suppressor protein p53, and BAX has been shown to be involved in p53-mediated apoptosis (PMID: 8183579).

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