BCL2兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210040L BCL2兔多克隆抗体 200ul 2800

Applications

Tested Applications:
FC, IHC, IP, WB,ELISA

Cited Applications:
chIP, CoIP, FC, IF, IHC, IP, WB
Species Specificity:
human

Cited Species:
Astragalus membranaceus, bovine, canine, chicken, fish, goat, hamster, Hu Sheep, human, pig

Positive WB detected in:
HL-60 cells, HepG2 cells, Jurkat cells, U-251 cells, HEK-293 cells, U-937 cells

Positive IP detected in:
HL-60 cells, HepG2 cells, MCF-7 cells

Positive IHC detected in:
human tonsillitis tissue, human breast cancer tissue, human colon cancer tissue, human lymphoma tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive FC detected in:
Jurkat cells, human peripheral blood lymphocytes

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:300

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
B-cell CLL/lymphoma 2

Calculated molecular weight:
26 kDa

Observed molecular weight:
25-30 kDa

Gene symbol
BCL2

Synonyms
Apoptosis regulator Bcl 2, B cell CLL/lymphoma 2, BCL2, BCL-2, Oncogene B cell leukemia 2

Background

BCL2 belongs to the Bcl-2 family. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. BCL2 regulates cell death by controlling the mitochondrial membrane permeability (PMID: 10365962). It appears to function in a feedback loop system with caspases. BCL2 inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (PMID: 10444588). This antibody is not suitable for rat and mouse species.

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