BCL2L1兔多克隆抗体

品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210038M BCL2L1兔多克隆抗体 100ul 1960

Applications

Tested Applications:
FC, IF, IHC, IP, WB,ELISA

Cited Applications:
ChIP, IHC, WB

Species Specificity:
human, mouse, rat

Cited Species:
goat, human, mouse, rat, sheep, zebrafish

Positive WB detected in:
A549 cells, Raji cells, mouse placenta tissue, HepG2 cells, C6 cells, Jurkat cells, K-562 cells, human placenta tissue, NIH/3T3 cells, RAW264.7, HeLa cells, rat brain tissue

Positive IP detected in:
K-562 cells

Positive IHC detected in:
human lung cancer tissue, human colon tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
NIH/3T3 cells

Positive FC detected in:
Jurkat cells

Recommended dilution:
WB : 1:1000-1:4000
IP : 0.5-4.0 ug for IP and 1:500-1:1000 for WB
IHC : 1:50-1:500
IF : 1:10-1:100

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
BCL2-like 1

Calculated molecular weight:
26 kDa

Observed molecular weight:
30 kDa

Gene symbol
BCL2L1

Synonyms
Apoptosis regulator Bcl X, BCL2L1, Bcl-XL

Background

BCL2L1 is a member of the BCL-2 protein family. BCL2L1 is expressed as three isoforms, Bcl-X(L),Bcl-X(s) and Bcl-X(beta) , and is located at the outer mitochondrial membrane. The Bcl-X(L) isoform is a 233 amino acid protein, acting as an apoptotic inhibitor. Bcl-XL can forms heterodimers with BAX, BAK or BCL2, and the heterodimerization with BAX does not seem to be required for anti-apoptotic activity. The Bcl-X(s) isoform is a shorter variant that is 178 amino acids in length and lacks a 63 amino acid region (amino acids 126-188), acting as an apoptotic activator. Bcl-X(beta) is a 227 amino acid protein. This antibody can recognize Bcl-XL, Bcl-X(s) and Bcl-X(Beta).

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