ARL13B兔多克隆抗体

一抗 3490
品牌 商品编码 商品名称 规格 单位 单价
KAOKEBIO HK210015L ARL13B兔多克隆抗体 200ul 2800

Applications

Tested Applications:
IF, IHC, IP, WB,ELISA

Cited Applications:
IF, IHC, IP, WB
Species Specificity:
human, mouse, rat, Canine

Cited Species:
canine, chicken, human, mouse, pig, rat, sheep, Xenopus, zebrafish

Positive WB detected in:
mouse liver tissue, NIH/3T3 cells, L02 cells, mouse kidney tissue, rat liver tissue, mouse brain tissue

Positive IP detected in:
L02 cells

Positive IHC detected in:
mouse brain tissue, human testis tissue, human liver tissue, human kidney tissue

Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0


Positive IF detected in:
MDCK cells, hTERT-RPE1, mouse embryonic fibroblasts, NIH3T3 cells

Recommended dilution:
WB : 1:500-1:2000
IP : 0.5-4.0 ug for IP and 1:500-1:2000 for WB
IHC : 1:50-1:500
IF : 1:50-1:500

Product Information


Source:
Rabbit

Purification method:
Antigen affinity purification

Isotype:
IgG

Storage:
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Immunogen Information


Full name:
ADP-ribosylation factor-like 13B

Calculated molecular weight:
48 kDa

Observed molecular weight:
40-48 kDa, 66 kDa
Gene symbol
ARL13B

Synonyms
ARL13B, ARL2 like protein 1, ARL2L1, JBTS8

Background

ARL13B, also named as ARL2L1, is a small ciliary G protein of the Ras superfamily. Localized in the cilia, it is required for cilium biogenesis and sonic hedgehog signaling. Defects in ARL13B are the cause of Joubert syndrome (JS) which is an autosomal recessive disorder characterized by a distinctive cerebellar malformation (PMID: 19906870).This antibody detects two specific bands at 60 kDa and 48 kDa. Arl13b is predicted to be a 48 kDa protein, and the 60 kDa band is likely to represent a modified form of Arl13b. ARL13B can be used to mark the cilia (PMID:22072986).

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